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doi: 10.1080/19490976.2018.1445955 2 CerkKAguilera-GmezM

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4b) suggests that the metabolic response is mounted quickly but sustained and enhanced over time, given that ~75% of the metabolic DEGs at 24 h are also found at 48 h (Extended Data Fig

doi: 10.1111/bjd.14016 131 BelleiBPitisciAOttavianiMLudoviciMCotaCLuziFet al

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Altered Zn influx, efflux or buffering leads to intracellular zinc imbalance, which disrupts core molecular processes, including enzymatic activity, protein folding, signaling pathways and redox homeostasis